Resolution of Praziquantel
نویسندگان
چکیده
منابع مشابه
Resolution of Praziquantel
BACKGROUND Praziquantel remains the drug of choice for the worldwide treatment and control of schistosomiasis. The drug is synthesized and administered as a racemate. Use of the pure active enantiomer would be desirable since the inactive enantiomer is associated with side effects and is responsible for the extremely bitter taste of the pill. METHODOLOGY/PRINCIPAL FINDINGS We have identified ...
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BACKGROUND Treatment and morbidity control of schistosomiasis relies on a single drug, praziquantel. Hence, there is a pressing need to develop additional therapeutics against schistosomiasis. The antimalarial drug mefloquine shows antischistosomal activity in animal models and clinical trials, which calls for further investigations. METHODOLOGY We comparatively assessed the efficacy and tole...
متن کاملSURVEY OF PRAZIQUANTEL\'S EFFECT ON FASCIOLIASIS
Even though in some reputable references, praziquantel is still.a drug of choice for treatment of fascioliasis, but our study on 100 patients shows that it has no effect on the parasite.
متن کاملPraziquantel therapy in neurocysticercosis.
Neurocysticercosis is being recognised more often now, because of advances in radio-imaging. No treatment was available for this disease till about a decade back. Praziquantel has provided new hope. From India, there are very few published reports on experience with this drug. Nine cases of neurocysticercosis are being presented, where praziquantel therapy has been tried. Five patients with tum...
متن کاملThe cytotoxicity study of praziquantel enantiomers
Praziquantel (PZQ) is prescribed as a racemic mixture (racemic-PZQ, rac-PZQ), which is composed of (R)-PZQ and (S)-PZQ. In this work, the cytotoxicity of rac-PZQ and its two enantiomers (R)-PZQ and (S)-PZQ on eight cell lines (L-02, HepG2, prf-plc-5, SH-SY5Y, HUVEC, A549, HCT-15, Raw264.7) was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphe-nyltetrazolium bromide and lactate dehydrogenase a...
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ژورنال
عنوان ژورنال: PLoS Neglected Tropical Diseases
سال: 2011
ISSN: 1935-2735
DOI: 10.1371/journal.pntd.0001260